Tom Riley, the spokesman for the Administration's Drug Czar, John Walters, commented on the retirement of Keith Stroup, longtime leader of NORML (National Organization for the Reform of Marijuana Laws) by quoting the Big Lebowski:
"The '60s are over, Lebowski. The bums lost. My condolences."
I'm not sure Riley really got the quote--the speaker in the film was the millionaire Lebowski, a guy who moralized all of the time and got all of his money despite having never worked a day in his life.
Then again, maybe Riley did get the quote.